Critical role for CuZn-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice

摘要

Backgrounds and PurposeSuperoxide is associated with spontaneous intracerebral hemorrhage (ICH) during hypertension. The goal of this study was to test the hypothesis that changes in superoxide, in genetically altered mice with deletion and overexpression of CuZn-superoxide dismutase (SOD1), modulate susceptibility to ICH.