Low-calorie Cranberry Juice Decreases Lipid Oxidation and Increases Plasma Antioxidant Capacity in Women with Metabolic Syndrome

摘要

Cranberries, high in polyphenols have been associated with several cardiovascular health benefits, although limited clinical trials have been reported to validate these findings. We tested the hypothesis that commercially available low calorie cranberry juice (Ocean Spray Cranberries, Inc. MA, USA) will decrease surrogate risk factors of cardiovascular disease (CVD), such as, lipid oxidation, inflammation, and dyslipidemia, in subjects with metabolic syndrome. In a randomized double-blind placebo-controlled trial, participants identified with metabolic syndrome (n=15–16/group) were assigned to one of two groups: cranberry juice (480 mL/day) or placebo (480 mL/day) for 8 weeks. Anthropometrics, blood pressure measurements, dietary analyses, and fasting blood draws were conducted at screen and 8 weeks of the study. Cranberry juice significantly increased plasma antioxidant capacity (1.5±0.6 to 2.2±0.4 µmol/L [means ± SD], P<0.05) and decreased oxidized LDL and malondialdehyde (120.4±31.0 to 80.4±34.6 U/L and 3.4±1.1 to 1.7±0.7 µM, respectively, [means ± SD], P<0.05) at 8 weeks versus placebo. However, cranberry juice consumption caused no significant improvements in blood pressure, glucose and lipid profiles, C-reactive protein and interleukin-6. No changes in these parameters were noted in the placebo group. In conclusion, low-calorie cranberry juice (2 cups/day) significantly reduces lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome.