In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format

摘要

A two-stage synthesis of lactams in flow is described. Thus, a keto alkyl halide is displaced in a microwave-assisted, continuous flow organic synthesis format (MACOS) to generate a reactive alkyl azide. Without isolation, a flowed solution containing this azide is then combined with TFA to afford a lactam.