Siloxyl-Ether Functionalized Resins for Chemoselective Enrichment of Carboxylic Acids

摘要

Although the carboxylic acid moiety is prevalent in many biologically produced molecules, including natural products and proteins, methods to chemoselectively target this functional group have remained elusive. Generally, strategies that utilize carboxylate nucleophilicity also promote reactions with other nucleophiles such as amines and hydroxyls. A reagent was sought to facilitate the selective isolation of carboxylic acid-containing compounds from complex mixtures. Here, the development of siloxyl-ether functionalized solid supports is described.