A Reported New Synthesis of Lysergic Acid Yields Only The Derailment Product: Methyl 5- methoxy-45-dihydroindolo43- fgquinoline-9-carboxylate

摘要

The treatment of ethyl 6-formyl-5-(1H-indol-4-yl)pyridine-3-carboxylate (2) with NaOMe or NaOH in methanol solution at room temperature under the reported reaction conditions afforded solely product 4 in 80% yield, rather than anticipated product 3.