Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma

摘要

Background & AimsWell established risk factors for intrahepatic cholangiocarcinoma such as biliary tract inflammation and liver flukes are not present in most patients in Western countries. Although cirrhosis and other causes of chronic liver disease have been implicated, their contribution as risk factors for cholangiocarcinoma is unclear and our aims were to analyze these emerging potential risk factors by systematic examination of case-control series from geographically diverse regions.