Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats

摘要

BackgroundLevodopa (L-dopa) is the most commonly used treatment for alleviating symptoms of Parkinson's disease. However, L-dopa delays gastric emptying, which dampens its absorption. We investigated whether ghrelin prevents L-dopa action on gastric emptying and enhances circulating L-dopa in rats.