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Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls

机译:在14岁男孩的生殖激素谱和青春期发育暴露于多氯联苯

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摘要

Because polychlorinated biphenyls (PCBs) are thought to cause endocrine disruption, we examined 438 adolescent boys from a birth cohort in the Faroe Islands, where PCB exposures are elevated. We measured PCBs and p,p′-dichlorodiphenyldichloroethylene (DDE) in cord blood and in serum from clinical examination at age 14. Higher prenatal PCB exposure was associated with lower serum concentrations of both luteinizing hormone (LH) and testosterone. In addition, sex hormone binding globulin (SHBG) was positively associated with both prenatal and concurrent PCB exposures. The PCB-SHBG association was robust to covariate adjustment. In a structural equation model, a doubling in prenatal PCB exposure was associated with a decrease in LH of 6% (p = 0.03). Prenatal exposure to PCB and DDE showed weak, non-significant inverse associations with testicular size and Tanner stage. DDE was highly correlated with PCB and showed slightly weaker associations with the hormone profile. These findings suggest that delayed puberty with low serum-LH concentrations associated with developmental exposure to non dioxin-like PCBs may be due to a central hypothalamo-pituitary mechanism.
机译:由于人们认为多氯联苯(PCBs)会引起内分泌干扰,因此我们检查了法罗群岛(Faroe Islands)438个出生队列中的青少年男孩,那里的PCB暴露水平较高。我们从14岁开始的临床检查中测量了脐带血和血清中的PCBs和p,p'-dichlorodiphenyldichloroethylene(DDE),产前PCB暴露量较高与黄体生成激素(LH)和睾丸激素水平降低有关。此外,性激素结合球蛋白(SHBG)与产前和并发PCB暴露均呈正相关。 PCB-SHBG关联对协变量调整具有鲁棒性。在结构方程模型中,产前PCB暴露量加倍与LH降低6%有关(p = 0.03)。产前暴露于PCB和DDE的情况与睾丸大小和Tanner分期呈弱,非显着的负相关。 DDE与PCB高度相关,并且与激素谱的关联略弱。这些发现提示,青春期低血清LH浓度与非二恶英样PCBs发育暴露相关的青春期延迟可能是由于中央下丘脑-垂体机制引起的。

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