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Monoamine oxidase A expression is suppressed in human cholangiocarcinoma via coordinated epigenetic and IL-6-driven events

机译:单胺氧化酶通过协调的表观遗传和IL-6驱动的事件在人胆管癌中抑制了表达

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摘要

ObjectivesThe secretion of dopamine and serotonin is increased in cholangiocarcinoma, which has growth-promoting effects. Monoamine oxidase A (MAOA), the degradation enzyme of serotonin and dopamine, is suppressed in cholangiocarcinoma via an unknown mechanism. The aims of this study were to (i) correlate MAOA immunoreactivity with pathophysiological parameters of cholangiocarcinoma, (ii) determine the mechanism by which MAOA expression is suppressed and (iii) evaluate the consequences of restored MAOA expression in cholangiocarcinoma.
机译:目的在胆管癌中增加多巴胺和5-羟色胺的分泌,具有促进生长的作用。单胺氧化酶A(MAOA)是血清素和多巴胺的降解酶,在胆管癌中通过未知机制被抑制。这项研究的目的是(i)使MAOA免疫反应性与胆管癌的病理生理参数相关,(ii)确定抑制MAOA表达的机制,以及(iii)评估恢复的MAOA表达在胆管癌中的后果。

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