USE OF CYPRIDINA LUCIFERIN ANALOG FOR ASSESSING THE MONOAMINE OXIDASE-LIKE SUPEROXIDE-GENERATING ACTIVITIES OF TWO PEPTIDE SEQUENCES CORRESPONDING TO THE HELICAL COPPER-BINDING MOTIF IN HUMAN PRION PROTEIN AND ITS MODEL ANALOG

摘要

@@INTRODUCTIONExperimental evidence for involvement of reactive oxygen species(ROS) such as H2O2,superoxide anion radicals(O2) and hydroxyl radicals(HO) in the toxic mechanism of prion protein(PrP) have been documented,suggesting that fundamental molecular mechanisms underlying the pathogenesis in neurodegenerative diseases could be attributed to the production of ROS that stimulates the formation of abnormal protein aggregates.