Melatonin in the Afternoons of a Gradually Advancing Sleep Schedule Enhances the Circadian Rhythm Phase Advance

摘要

RationaleWe test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested 1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin; and 2) the same sleep schedule with only morning bright light. Now we report on the same sleep schedule with only afternoon/evening melatonin.