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The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma

机译:地塞米松的影响及某些抗氧化剂维生素在实验性支气管哮喘发病中的作用

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摘要

BackgroundBronchial asthma is a disease characterized by paroxysmal and reversible obstruction of the airways. The imbalance between the oxidant and antioxidant system that is called oxidative stress is critical in asthma pathogenesis. It is likely, therefore, that antioxidants may be effective in the treatment of asthma. Systemic treatment with glucocorticoids has been reported to inhibit smooth muscle hypercontraction which may account partially for their beneficial effects in the treatment of asthma.
机译:背景技术支气管哮喘是一种以阵发性和可逆性气道阻塞为特征的疾病。氧化剂和抗氧化剂系统之间的不平衡(称为氧化应激)在哮喘发病机理中至关重要。因此,抗氧化剂可能有效治疗哮喘。已经报道用糖皮质激素的全身治疗抑制平滑肌过度收缩,这可能部分解释了它们在哮喘治疗中的有益作用。

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