Ring around the Ro-sie: RNA-mediated alterations of PNPase activity

摘要

Chen et al. demonstrate a new way by which non-coding RNAs tailor the function of multi-component complexes. They show that a non-coding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold, and perhaps a gate for entry of the RNA substrate.