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Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes

机译：NO合酶和NADPH氧化酶之间的相互作用在控制糖尿病患者肾厚上升肢体钠转运中的作用

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摘要

AimDuring type 1 diabetes (T1D), the medullary thick ascending limb (mTAL) displays an NADPH oxidase-dependent increase in sodium transport, in concert with increased NO production by NO synthase 1 (NOS1) and NOS2. We hypothesized that NOS1- and/or NOS2-derived NO blunts T1D-induced activation of sodium transport in the mTAL.

机译：目的在1型糖尿病（T1D）中，髓质粗大上升肢（mTAL）表现出NADPH氧化酶依赖性的钠转运增加，与NO合酶1（NOS1）和NOS2的NO产生增加相一致。我们假设NOS1和/或NOS2衍生的NO钝化T1D诱导的mTAL中钠转运的激活。

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期刊名称 other
作者
Carmen De Miguel; Jan M. Foster; Pamela K. Carmines; Jennifer S. Pollock;
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年(卷),期 -1(209),2
年度 -1
页码 12144
总页数 13
原文格式 PDF
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关键词
Streptozotocin-induced diabetes nitric oxide nitric oxide synthase superoxide NADPH oxidase sodium transport;

机译：链脲佐菌素诱发的糖尿病;一氧化氮;一氧化氮合酶;超氧化物;NADPH氧化酶;钠转运;

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专利

1. NADPH Oxidase and PKC Contribute to Increased Na Transport by the Thick Ascending Limb During Type 1 Diabetes [J] . Jing Yang, Jennifer S. Pollock, Pamela K. Carmines Hypertension: An Official Journal of the American Heart Association . 2012,第2aPta2期

机译：NADPH氧化酶和PKC促进1型糖尿病患者中浓密的上肢增加Na转运。
2. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. [J] . Yang J, Pollock JS, Carmines PK Hypertension: An Official Journal of the American Heart Association . 2012,第2期

机译：在1型糖尿病中，NADPH氧化酶和PKC促进了由上肢粗大上升的Na转运。
3. NADPH Oxidase and PKC Contribute to Increased Na Transport by the Thick Ascending Limb During Type 1 Diabetes [J] . Jing Yang, Jennifer S. Pollock, Pamela K. Carmines Hypertension: An Official Journal of the American Heart Association . 2012,第2aPta2期

机译：NADPH氧化酶和PKC促进1型糖尿病患者中浓密的上肢增加Na转运。
4. The role of NADPH oxidase and ROS in islet inflammation, oxidative stress and diabetes [C] . P. Newsholme Europe Meeting of the Society for Free Radical Research . 2009

机译：NADPH氧化酶和RO在胰岛炎症，氧化应激和糖尿病中的作用
5. Regulation of endothelial nitric oxide synthase by subcellular localization and NADPH oxidase. [D] . Zhang, Qian. 2007

机译：亚细胞定位和NADPH氧化酶对内皮型一氧化氮合酶的调节。
6. Molecular Mechanism of Renal Tubule Transport: NADPH oxidase 4-derived superoxide mediates flow-stimulated NKCC2 activity in thick ascending limbs [O] . Fara Saez, Nancy J. Hong, Jeffrey L. Garvin -1

机译：肾小管运输的分子机制：NADPH氧化酶4衍生的超氧化物介导了厚肢上升流中经流量刺激的NKCC2活性。
7. Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes [O] . C. De Miguel, J. M. Foster, P. K. Carmines, 2013

机译：糖尿病患者肾厚升肢的钠转运中NO合酶和NADPH氧化酶之间的相互作用

Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes

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