HIV nucleoside reverse transcriptase inhibitors efavirenz and tenofovir change the growth and differentiation of primary gingival epithelium

摘要

BackgroundAn increasing number of human immunodeficiency virus (HIV) patients are combating HIV infection through antiretroviral drugs including reverse transcriptase inhibitors. Oral complications associated with these drugs are becoming a mounting concern. In our previous studies, both protease inhibitors and reverse transcriptase inhibitors have been shown to change the proliferation and differentiation state of oral tissues. This study examines the effect of a non-nucleoside and a nucleoside reverse transcriptase inhibitor on the growth and differentiation of gingival epithelium.