THE ROLE OF SON IN SPLICING DEVELOPMENT AND DISEASE

摘要

SON is a nuclear protein involved in multiple cellular processes including transcription, pre-mRNA splicing and cell cycle regulation. Although SON was discovered 25 years ago, the importance of SON’s function was only realized recently when its roles in nuclear organization and pre-mRNA splicing as well as the influence of these activities in maintaining cellular health were unveiled. Furthermore, SON was implicated to have a key role in stem cells as well as during the onset of various diseases such as cancer, influenza, and hepatitis. Here we review the progress that has been made in studying this multi-functional protein and discuss questions that remain to be answered about SON.