Hyperinflammation rather than hemophagocytosis is the common link between Macrophage Activation Syndrome and Hemophagocytic Lymphohistiocytosis

摘要

Purpose of ReviewMacrophage activation syndrome is the rheumatic disease-associated member of a group of hyperinflammatory syndromes characterized by uncontrolled cytokine storm. In this review, we highlight recent publications related to the pathoetiology of hyperinflammatory syndromes with an emphasis on how this new knowledge will guide our diagnosis, treatment, and future research efforts to better understand these deadly conditions.