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Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

机译：Nogo受体抑制增强溶血卵磷脂诱导的小鼠视交叉脱髓鞘后的功能恢复。

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BackgroundInhibitory factors have been implicated in the failure of remyelination in demyelinating diseases. Myelin associated inhibitors act through a common receptor called Nogo receptor (NgR) that plays critical inhibitory roles in CNS plasticity. Here we investigated the effects of abrogating NgR inhibition in a non-immune model of focal demyelination in adult mouse optic chiasm.

机译：背景技术抑制因素与脱髓鞘疾病中的髓鞘再生失败有关。髓磷脂相关的抑制剂通过称为Nogo受体（NgR）的共同受体起作用，该受体在CNS可塑性中起关键抑制作用。在这里，我们研究了在成年小鼠视神经干性局灶性脱髓鞘的非免疫模型中取消NgR抑制的作用。

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Fereshteh Pourabdolhossein; Sabah Mozafari; Ghislaine Morvan-Dubois; Javad Mirnajafi-Zadeh; Alejandra Lopez-Juarez; Jacqueline Pierre-Simons; Barbara A. Demeneix; Mohammad Javan;
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年(卷),期 -1(9),9
年度 -1
页码 e106378
总页数 13
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专利

1. PREGABALIN ENHANCES MYELIN REPAIR AND ATTENUATES GLIAL ACTIVATION IN LYSOLECITHIN-INDUCED DEMYELINATION MODEL OF RAT OPTIC CHIASM [J] . Daneshdoust Danyal, Khalili-Fomeshi Mohsen, Ghasemi-Kasman Maryam, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2017,第期

机译：普瑞巴林增强骨髓素修复并衰减溶血性诱导的大鼠光学Chiasm脱髓鞘模型中的胶质激活
2. Fingolimod improves the functional recovery of optic pathway and alleviates the expression level of histone deacetylase/sphingosine 1 phosphate receptor 1 in focal demyelination model of rat's optic chiasm [J] . Mona Hashemian, Hadi Parsian, Farzin Sadeghi, IBRO Reports . 2019,第1期

机译：芬戈莫德改善大鼠视交叉症局灶性脱髓鞘模型中视神经通路的功能恢复并减轻组蛋白脱乙酰基酶/鞘氨醇1磷酸受体1的表达水平
3. Co-administration of aspirin and adipose-derived stem cell conditioned medium improves the functional recovery of the optic pathway in a lysolecithin-induced demyelination model [J] . Adel Galeshi, Maryam Ghasemi-Kasman, Farideh Feizi, Neuropsychiatric Disease and Treatment . 2019,第6期

机译：阿司匹林和脂肪干细胞条件培养基的共同给药可改善溶血卵磷脂诱导的脱髓鞘模型中光通路的功能恢复
4. Functional inhibition of cell surface and intracellular receptors mediated by ER intrabodies [C] . Boldicke T., Bernal M., Somplatzki S., European Congress of Immunology . 2009

机译：ER内部介导的细胞表面和细胞内受体的功能抑制
5. Pharmacological and functional characterization of the sigma-1 receptor: Studies utilizing sigma-1 receptor photoprobes and the sigma-1 null homozygous mouse. [D] . Fontanilla, Dominique A. 2010

机译：sigma-1受体的药理和功能表征：利用sigma-1受体光电探针和sigma-1 null纯合小鼠的研究。
6. Co-administration of aspirin and adipose-derived stem cell conditioned medium improves the functional recovery of the optic pathway in a lysolecithin-induced demyelination model [O] . Adel Galeshi, Maryam Ghasemi-Kasman, Farideh Feizi, 2019

机译：阿司匹林和脂肪干细胞条件培养基的共同给药可改善溶血卵磷脂诱导的脱髓鞘模型中光通路的功能恢复
7. Nogo receptor inhibition enhances functional recovery following lysolecithin-induced demyelination in mouse optic chiasm. [O] . Fereshteh Pourabdolhossein, Sabah Mozafari, Ghislaine Morvan-Dubois, 2014

机译：Nogo受体抑制增强了小鼠视交叉中溶血卵磷脂诱导的脱髓鞘后的功能恢复。

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

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