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Optical Coherence Tomography Guided Laser Cochleostomy: Towards the Accuracy on Tens of Micrometer Scale

机译:光学相干断层扫描术指导的激光耳蜗切开术:达到数十微米尺度的精度

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摘要

Lasers have been proven to be precise tools for bone ablation. Applying no mechanical stress to the patient, they are potentially very suitable for microsurgery on fragile structures such as the inner ear. However, it remains challenging to control the laser-bone ablation without injuring embedded soft tissue. In this work, we demonstrate a closed-loop control of a short-pulsed CO2 laser to perform laser cochleostomy under the monitoring of an optical coherence tomography (OCT) system. A foresighted detection of the bone-endosteum-perilymph boundary several hundred micrometers before its exposure has been realized. Position and duration of the laser pulses are planned based on the residual bone thickness distribution. OCT itself is also used as a highly accurate tracking system for motion compensation between the target area and the optics. During ex vivo experimental evaluation on fresh porcine cochleae, the ablation process terminated automatically when the thickness of the residual tissue layer uniformly reached a predefined value. The shape of the resulting channel bottom converged to the natural curvature of the endosteal layer without injuring the critical structure. Preliminary measurements in OCT scans indicated that the mean absolute accuracy of the shape approximation was only around 20 μm.
机译:激光已被证明是用于骨消融的精确工具。在不对患者施​​加任何机械压力的情况下,它们很可能非常适合在脆弱结构(例如内耳)上进行显微外科手术。然而,在不损伤嵌入的软组织的情况下控制激光骨消融仍然具有挑战性。在这项工作中,我们演示了在光学相干断层扫描(OCT)系统的监视下,对短脉冲CO2激光器进行激光耳蜗切开术的闭环控制。在暴露前先对骨-内膜-外周淋巴边界进行数百微米的预见性检测。根据残余的骨厚度分布计划激光脉冲的位置和持续时间。 OCT本身也用作高度精确的跟踪系统,用于目标区域和光学元件之间的运动补偿。在对新鲜猪耳蜗进行离体实验评估期间,当残留组织层的厚度均匀达到预定值时,消融过程会自动终止。所形成的通道底部的形状在不损害关键结构的情况下收敛到了骨内膜层的自然曲率。 OCT扫描的初步测量表明,形状近似的平均绝对精度仅为20μm左右。

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