P-selectin Inhibition Therapeutically Promotes Thrombus Resolution and Prevents Vein Wall Fibrosis Better than Enoxaparin and an Inhibitor to von Willebrand Factor

摘要

ObjectiveAptamers are oligonucleotides targeting protein/protein interactions with pharmacokinetic profiles and activity reversal options. Although P-selectin and von Willebrand factor (VWF) have been implicated in the development of venous thrombosis (VT), no studies have directly compared aptamer efficacy with standard of care in VT. In this study, ARC5692, an anti-P-selectin aptamer, and , an anti- VWF aptamer, were compared to low molecular weight heparin, enoxaparin, to test the efficacy of P-selectin or VWF inhibition in promoting thrombus resolution and preventing vein wall fibrosis, in a baboon model of VT.