Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice

摘要

BackgroundDiabetic heart disease is associated with tetrahydrobiopterin (BH4) oxidation and high arginase activity, leading to endothelial nitric oxide synthase (eNOS) dysfunction. Sepiapterin (SEP) is a BH4 precursor, and L-citrulline (L-Cit) is converted to eNOS substrate, L-arginine. Whether SEP and L-Cit are effective at reducing diabetic heart disease is not known. The present study examined the effects of SEP and L-Cit on diabetic cardiomyopathy and ischemia/reperfusion injury in obese type 2 diabetic mice.