Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors

摘要

Background & AimsSmall intestinal neuroendocrine tumors (SI-NET) are serotonin-secreting well-differentiated neuroendocrine tumors believed to originate from enterochromaffin (EC) cells. Intestinal stem cell (ISC) are believed to contribute to formation of SI-NET, although little is known about tumor formation or development. We investigated the relationship between EC cells, ISCs, and SI-NETs.