State-of-the-Art Metabolic Toxicity Screening and Pathway Evaluation

摘要

Routine in vitro bioassays and animal toxicity studies of drug and environmental chemical candidates fail to reveal toxicity in ~30% of cases. This Feature article addresses research on new approaches to in vitro toxicity testing as well as our own efforts to produce high-throughput genotoxicity arrays and LC–MS/MS approaches to reveal possible chemical pathways of toxicity.