Plasma 25-hydroxyvitamin D3 levels in colorectal cancer patients and associations with physical activity

摘要

Physical activity (PA) and vitamin D are thought to affect colorectal cancer prognosis. The present study investigates associations between 25(OH)D3 and PA in prospectively followed colorectal cancer patients in the ColoCare study.At 6, 12 and 24 months after surgery patients donated a blood sample, wore an accelerometer for 10 consecutive days and completed a PA questionnaire. Plasma 25(OH)D3 levels were measured by high performance liquid chromatography. We tested associations using partial correlations and multivariate linear regression analysis, adjusted for season, age and BMI. A total of 137 assessments of 25(OH)D3 levels and physical activity were conducted (58 at 6 months, 51 at 12 months and 28 at 24 months). More than 60% of the patients were vitamin D deficient (25(OH)D3 ≤20ng/mL), independent of study time point. At 6 months follow-up, accelerometry-based vigorous and moderate-to-vigorous physical activity were positively associated with 25(OH)D3 levels (P=0.04; P=0.006,). Physical activity together with season were significant predictors of elevated 25(OH)D3 levels.Our results suggest that the majority of colorectal cancer patients may suffer from vitamin D deficiency. Engaging in physical activity may be an effective approach to increase their 25(OH)D3 levels.