Synthesis Biological Evaluation and Modeling Studies of New Pyrido34-bindole Derivatives as Broad-Spectrum Potent Anticancer Agents

摘要

ObjectiveThere is an urgent need drugs against particularly difficult to treat solid tumors such as pancreatic, triple negative breast, lung, colon, metastatic prostate cancers and melanoma. Thus, the objective of this study was to synthesize compounds based computational modeling that indicated the pyrido[3,4-b]indole class bind to MDM2, a new cancer target for which there are still no drug on the market.