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ImmunoPET of malignant and normal B cells with 89Zr- and 124I-labeled obinutuzumab antibody fragments reveals differential CD20 internalization in vivo

机译：带有89Zr和124I标记的obinutuzumab抗体片段的恶性和正常B细胞的ImmunoPET显示体内CD20差异化

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摘要

PurposeThe B-cell antigen CD20 provides a target for antibody-based positron emission tomography (immunoPET). We engineered antibody fragments targeting human CD20 and studied their potential as immunoPET tracers in transgenic mice (huCD20TM) and in a murine lymphoma model expressing human CD20.

机译：目的B细胞抗原CD20为基于抗体的正电子发射断层扫描（immunoPET）提供靶标。我们设计了针对人CD20的抗体片段，并研究了它们在转基因小鼠（huCD20TM）和表达人CD20的鼠淋巴瘤模型中作为免疫PET示踪剂的潜力。

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期刊名称 other
作者
Kirstin A. Zettlitz; Richard Tavaré; Scott M. Knowles; Kristopher K. Steward; John M. Timmerman; Anna M. Wu;
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年(卷),期 -1(23),23
年度 -1
页码 7242–7252
总页数 20
原文格式 PDF
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关键词
immunoPET antibody fragments B-cell lymphoma Zirconium-89 Iodine-124;

机译：免疫PET;抗体片段;B细胞淋巴瘤;锆89;碘124;

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专利

1. ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo [J] . Zettlitz Kirstin A., Tavare Richard, Knowles Scott M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第23期

机译：具有Zr-89-和I-124标记的obInutuzumab抗体片段的恶性和正常B细胞免疫潜水蛋白揭示了体内差异CD20内化
2. Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: In vivo carbonic anhydrase IX receptor binding and internalization in mouse xenografts of clear-cell renal cell carcinoma [J] . ChealS.M., PunzalanB., DoranM.G., European Journal of Nuclear Medicine and Molecular Imaging . 2014,第5期

机译：基于正电子发射断层扫描成像和非线性免疫动力学建模的89Zr和124I标记的cG250的成对比较：透明细胞肾细胞癌小鼠异种移植物中的体内碳酸酐酶IX受体结合和内在化
3. Differential regulation patterns of the anti-CD20 antibodies obinutuzumab and rituximab in mantle cell lymphoma [J] . Heinrich Daniel A., Weinkauf Marc, Hutter Grit, British Journal of Haematology . 2015,第Pta4期

机译：抗CD20抗体obinutuzumab和rituximab在套细胞淋巴瘤中的差异调节模式
4. Differential proteomic characterization of B cell proliferative states: analysis of tumor-specific and proliferation-specific proteomes in normal and malignant B cells [C] . Paul B. Romesser, David H. Perlman, Anupama Sinha, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：B细胞增殖状态的差分蛋白质组学表征：正常和恶性B细胞中肿瘤特异性和增殖特异性蛋白质组的分析
5. Engineered antibody fragments for the targeting and imaging of prostate stem cell antigen (PSCA)-expressing xenografts in vivo by microPET [D] . Leyton, Victor Jeffrey 2008

机译：通过microPET在体内靶向和成像表达前列腺干细胞抗原（PSCA）的异种移植物的工程化抗体片段
6. Pairwise Comparison of 89Zr- and 124I-labeled cG250 Based on Positron Emission Tomography Imaging and Non-Linear Immunokinetic Modeling: In Vivo Carbonic Anhydrase IX Receptor Binding and Internalization in Mouse Xenografts of Clear Cell Renal Carcinoma [O] . Sarah M. Cheal, Blesida Punzalan, Michael G. Doran, -1

机译：基于正电子发射断层扫描成像和非线性免疫动力学建模的89Zr和124I标记的cG250的成对比较：透明碳肾癌小鼠异种移植物中的体内碳酸酐酶IX受体结合和内在化
7. ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo [O] . Kirstin A. Zettlitz, Richard Tavaré, Scott M. Knowles, 2017

机译：具有89zr-和124i标记的obinutuzumab抗体片段的恶性和正常B细胞的免疫潜水蛋白揭示了体内差异CD20内化
8. Development of Methodology to Maintain Primary Cultures of Normal and Malignant Human Prostatic Epithelial Cells In Vivo; Final rept. 15 Jan 2004-14 Jan 2008 [R] . Peehl, D. M. 2008

机译：维持正常和恶性人前列腺上皮细胞原代培养方法学的发展;最终评论2004年1月15日至2008年1月

ImmunoPET of malignant and normal B cells with 89Zr- and 124I-labeled obinutuzumab antibody fragments reveals differential CD20 internalization in vivo

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