ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo

Zettlitz Kirstin A.; Tavare Richard; Knowles Scott M.; Steward Kristopher K.; Timmerman John M.; Wu Anna M.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo

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ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo

机译：具有Zr-89-和I-124标记的obInutuzumab抗体片段的恶性和正常B细胞免疫潜水蛋白揭示了体内差异CD20内化

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Purpose: The B-cell antigen CD20 provides a target for antibody-based positron emission tomography (immunoPET). We engineered antibody fragments targeting human CD20 and studied their potential as immunoPET tracers in transgenic mice (huCD20TM) and in a murine lymphoma model expressing human CD20.

机译：目的：B细胞抗原CD20提供基于抗体的正电子发射断层扫描（Immunopet）的靶标。我们设计了靶向人CD20的抗体片段，并在转基因小鼠（HUCD20TM）中和表达人CD20的小鼠淋巴瘤模型中研究其作为免疫捕集器的潜力。

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《Clinical cancer research: an official journal of the American Association for Cancer Research 》 |2017年第23期| 共11页
作者
Zettlitz Kirstin A.; Tavare Richard; Knowles Scott M.; Steward Kristopher K.; Timmerman John M.; Wu Anna M.;
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作者单位

Univ Calif Los Angeles David Geffen Sch Med Dept Mol &

Med Pharmacol Crump Inst Mol Imaging Los;

Univ Calif Los Angeles David Geffen Sch Med Dept Mol &

Med Pharmacol Crump Inst Mol Imaging Los;

Univ Calif Los Angeles David Geffen Sch Med Dept Mol &

Med Pharmacol Crump Inst Mol Imaging Los;

Univ Calif Los Angeles Dept Med Div Hematol &

Oncol Los Angeles CA 90024 USA;

Univ Calif Los Angeles Dept Med Div Hematol &

Oncol Los Angeles CA 90024 USA;

Univ Calif Los Angeles David Geffen Sch Med Dept Mol &

Med Pharmacol Crump Inst Mol Imaging Los;

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正文语种 eng
中图分类肿瘤学 ;
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1. ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo [J] . Zettlitz Kirstin A., Tavare Richard, Knowles Scott M., Clinical cancer research: an official journal of the American Association for Cancer Research . 2017 ,第23期

机译：具有Zr-89-和I-124标记的obInutuzumab抗体片段的恶性和正常B细胞免疫潜水蛋白揭示了体内差异CD20内化
2. Differential regulation patterns of the anti-CD20 antibodies obinutuzumab and rituximab in mantle cell lymphoma [J] . Heinrich Daniel A., Weinkauf Marc, Hutter Grit, British Journal of Haematology . 2015 ,第Pta4期

机译：抗CD20抗体Obinutuzumab和Rituximab的差分调节模式在搭式细胞淋巴瘤中
3. Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells. [J] . Beum PV, Peek EM, Lindorfer MA, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2011 ,第6期

机译：由于表达Fc受体的效应细胞介导的吞噬作用，与调理B细胞的CD20和结合的CD20抗体相比，B细胞直接内在化的速度更快。
4. Differential proteomic characterization of B cell proliferative states: analysis of tumor-specific and proliferation-specific proteomes in normal and malignant B cells [C] . Paul B. Romesser, David H. Perlman, Anupama Sinha, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：B细胞增殖状态的差分蛋白质组学表征：正常和恶性B细胞中肿瘤特异性和增殖特异性蛋白质组的分析
5. Engineered antibody fragments for the targeting and imaging of prostate stem cell antigen (PSCA)-expressing xenografts in vivo by microPET [D] . Leyton, Victor Jeffrey 2008

机译：通过microPET在体内靶向和成像表达前列腺干细胞抗原（PSCA）的异种移植物的工程化抗体片段
6. ImmunoPET of malignant and normal B cells with 89Zr- and 124I-labeled obinutuzumab antibody fragments reveals differential CD20 internalization in vivo [O] . Kirstin A. Zettlitz, Richard Tavaré, Scott M. Knowles, -1

机译：带有89Zr和124I标记的obinutuzumab抗体片段的恶性和正常B细胞的ImmunoPET显示体内CD20差异化
7. ImmunoPET of Malignant and Normal B Cells with 89Zr- and 124I-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo [O] . Kirstin A. Zettlitz, Richard Tavaré, Scott M. Knowles, 2017

机译：具有89zr-和124i标记的obinutuzumab抗体片段的恶性和正常B细胞的免疫潜水蛋白揭示了体内差异CD20内化
8. Development of Methodology to Maintain Primary Cultures of Normal and Malignant Human Prostatic Epithelial Cells In Vivo; Final rept. 15 Jan 2004-14 Jan 2008 [R] . Peehl, D. M. 2008

机译：维持正常和恶性人前列腺上皮细胞原代培养方法学的发展;最终评论2004年1月15日至2008年1月

ImmunoPET of Malignant and Normal B Cells with Zr-89- and I-124-Labeled Obinutuzumab Antibody Fragments Reveals Differential CD20 Internalization In Vivo

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