A Humanized Antibody that binds to human CD20 or a fragment thereof, a composition, An article of manufacture a method to induce apoptosis in B cells in vivo, the use of these Antibodies for the manufacture of a Medicament for treating cancer, autoimmune diseases and arthritis Reum

摘要

A Humanized Antibody that binds to human CD20 Binding to antigen, or a fragment thereof, where the Antibody is effective in reducing B cells in vivo of primates, including the Antibody variable region of the H Chain (VH) CDr3 sequence of at least one sec. Id.No: 12 a CD20 Antibody anti Human Waste and essentially the Framework (FR) of Human consensus of Human heavy chain Subgroup III (vhiii), a composition, An article of manufacture comprising a Container and a composition comprising the Humanized Antibody that binds to CD2 0, a method for Inducing apoptosis in B cells in vivo.Use of these Antibodies for the manufacture of a Medicament for treating cancer, autoimmune diseases and rheumatoid arthritis, an isolated Nucleic Acid encoding Said Antibody, expression vector, host Cell; a method for producing a CD20 Antibody, Polypeptide Isolated and a Liquid formulation.