Age Differences by Sex in Antiretroviral-Naïve Participants: Pooled-Analysis from Randomized Clinical Trials

摘要

Age and sex effects on antiretroviral therapy (ART) response are not well elucidated. Our pooled-analysis of 40 randomized clinical trials measured the association of age and sex on CD4+ T cell count changes and virologic suppression using multivariable regression modeling. The average increase in CD4+ T cell count from baseline to week 48 was 17.3 cells/mm³ lower and clinically insignificant (95% CI: −30.8, −3.8) among women ≥ 50 years (n = 573) compared to women ≤ 35 years (n = 3,939). Results were similar for men. Virologic suppression odds were 60% and 21% times greater among participants ≥ 50 years compared to ≤ 35 years, in women and men, respectively. In both sexes, larger increases in CD4+ T cell count changes were observed in younger compared to older participants; however, virologic suppression was higher in older compared to younger participants suggesting a non-sex-specific age effect response to ART.