Determining the Upper and Lower Limits of Cerebral Autoregulation with Cerebral Oximetry Autoregulation Curves: A Case Series

摘要

ObjectiveCritical care guidelines recommend a single target value for mean arterial blood pressure (MAP) in critically ill patients. However, growing evidence regarding cerebral autoregulation (CA) challenges this concept and supports individualizing MAP targets to prevent brain and kidney hypo- or hyperperfusion. Regional cerebral oxygen saturation (rScO2) derived from near-infrared spectroscopy (NIRS) is an acceptable surrogate for cerebral blood flow and has been validated to measure CA. These data suggest a novel mechanism to construct autoregulation curves based on NIRS-measured cerebral oximetry.