The upper frequency limit of dynamic cerebral autoregulation

摘要

Key points Dynamic cerebral autoregulation (CA) is expressed by the temporal pattern of cerebral blood flow (CBF) recovery following a sudden change in arterial blood pressure (BP). Transfer function analysis of BP as input and CBF velocity as output can express dynamic CA through its amplitude (or gain) and phase frequency responses. The upper frequency limit ( F upLim ) at which dynamic CA can operate is of considerable physiological interest and can also provide additional information about worsening CA due to disease processes. In healthy subjects F upLim was strongly dependent on arterial P C O 2 changes induced by four different breathing manoeuvres. The considerable intersubject variability in F upLim suggests that fixed frequency bands should not be adopted for averaging values of gain and phase in studies of dynamic CA. Abstract Dynamic cerebral autoregulation (CA) can be expressed in the frequency domain by the amplitude and phase frequency responses calculated by transfer function analysis of arterial blood pressure (BP) and cerebral blood flow velocity (CBFV). We studied the effects of arterial P C O 2 ( P aC O 2 ) on the upper frequency limit ( F upLim ) of these responses and its intersubject variability. Twenty‐four healthy subjects (11 female, age 36.0?±?13.4?years) were recruited. Recordings of CBFV (transcranial Doppler ultrasound), BP (Finometer) and end‐tidal CO 2 ( P ETC O 2 , capnography) were performed during 5?min at rest (normocapnia) and during four breathing manoeuvres: 5% and 8% CO 2 in air and hyperventilation targeting reductions of 5 and 10?mmHg compared to normocapnia. F upLim was determined by the break point of the autoregulation index (ARI) curve as a function of frequency when the phase response was gradually set to zero. The five breathing conditions led to highly significant differences in P ETC O 2 ( p ??0.0001), CBFV ( P ??0.0001), ARI ( p ??0.0001) and F upLim ( p ??0.0001). F upLim ranged from 0.167?±?0.036?Hz at the lowest values of hypocapnia (28.1?±?1.9?mmHg) to 0.094?±?0.040?Hz at the highest level of hypercapnia (41.7?±?5.4?mmHg), showing a correlation of r ?=??0.53 ( p ??0.001) with P ETC O 2 . These findings reinforce the key role of P aC O 2 in CBF regulation. The considerable intersubject variability of F upLim suggests that fixed frequency bands should not be adopted for averaging values of gain and phase in dynamic CA studies, and that the higher frequency band (0.20–0.40?Hz), in particular, does not contain relevant information about dynamic CA. Further investigations are needed to assess the information value of F upLim as a marker of dynamic CA efficiency in physiological and clinical studies.