Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol

摘要

Using our previously designed biphenyl-2-ylphosphine >L2 featuring a remote tertiary amino group as an enabling ligand, we have developed the first gold-catalyzed intermolecular hydroalkenylation of alkynes. Synthetically valuable conjugated dienyl alcohols are formed in moderate to good yields. A range of alkenyltrifluoroborates are allowed as the alkenyl donor, and no erosion of alkene geometry and/or the propargylic configuration are detected. DFT calculations confirm the critical role of the remote basic group as a general base catalyst in promoting this novel gold catalysis in good efficiency.