Ruthenium- and Gold-Catalyzed Tandem Reaction: Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides

摘要

A convenient and straightforward one-pot reaction of propargylic alcohols bearing a terminal alkyne moiety with amides by the sequential action of ruthenium and gold catalysts gives the corresponding substituted oxazoles in good yields with a complete regioselectivity.