Gold-catalyzed dehydrative Friedel-Crafts reaction and Nazarov cyclization sequence: an efficient synthesis of 1,3-diarylindenes from propargylic alcohols

摘要

An efficient synthesis of 1,3-diarylindenes has been achieved from propargylic alcohols containing aromatic rings via gold-catalyzed dehydrative Friedel-Crafts reaction followed by gold-catalyzed Nazarov cyclization. The reaction proceeds via allene intermediates. (C) 2016 Published by Elsevier Ltd.