Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance without affecting insulin clearance in mice

摘要

The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood.OBJECTIVE:This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.