Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

机译：促炎细胞因子对人皮肤成纤维细胞中犬尿氨酸途径酶表达的影响

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BackgroundThe kynurenine pathway (KP) is the main route of tryptophan degradation in the human body and generates several neuroactive and immunomodulatory metabolites. Altered levels of KP-metabolites have been observed in neuropsychiatric and neurodegenerative disorders as well as in patients with affective disorders. The purpose of the present study was to investigate if skin derived human fibroblasts are useful for studies of expression of enzymes in the KP.

机译：背景犬尿氨酸途径（KP）是人体中色氨酸降解的主要途径，并产生多种神经活性和免疫调节代谢产物。在神经精神病和神经退行性疾病以及情感性疾病患者中，已观察到KP代谢物水平的改变。本研究的目的是研究皮肤来源的人成纤维细胞是否可用于研究KP中酶的表达。

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期刊名称 Journal of Inflammation (London England)
作者
Linnéa Asp; Anne-Sofie Johansson; Amandeep Mann; Björn Owe-Larsson; Ewa M Urbanska; Tomasz Kocki; Magdalena Kegel; Göran Engberg; Gabriella BS Lundkvist; Håkan Karlsson;
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年(卷),期 2011(8),-1
年度 2011
页码 25
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;
关键词
human fibroblast kynurenine pathway gene expression cytokine;

机译：人;成纤维细胞;犬尿氨酸途径;基因表达;细胞因子;

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专利

1. Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts [J] . Linnéa Asp, Anne-Sofie Johansson, Amandeep Mann, Journal of inflammation. . 2011,第11期

机译：促炎细胞因子对人真皮成纤维细胞中犬尿氨酸途径酶表达的影响
2. Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and after Acute Tryptophan Loading and Depletion: [J] . Abdulla A.-B. Badawy, Donald M. Dougherty International Journal of Tryptophan Research . 2016,第4期

机译：人Kynurenine途径的评估：基线和急性色氨酸负荷和耗尽后血浆色氨酸，Kynurenine代谢物和酶表达的种族和性别差异的比较和临床意义：
3. Gardenia jasminoidesExtract Attenuates the UVB-Induced Expressions of Cytokines in Keratinocytes and Indirectly Inhibits Matrix Metalloproteinase-1 Expression in Human Dermal Fibroblasts [J] . JiaaPark, Jin KyungSeok, Hwa-JinSuh, Evidence-based complementary and alternative medicine: eCAM . 2014,第2期

机译：茉莉子提取物减弱了UVB诱导的角质形成细胞中细胞因子的表达，并间接抑制了人类皮肤成纤维细胞中基质金属蛋白酶1的表达。
4. THE EXPRESSION OF COX-2 AND PRO-INFLAMMATORY CYTOKINES INDUCED BY PCB IN HUMAN MAST CELLS REQUIRES NF-k kk kB ACTIVATION [C] . O-Kyun Kwon, Eunkyung Lee, Tae Chul Moon, International symposium on halogenated environmental organic pollutants and persistent organic pollutants and POPs;DIOXIN;DIOXIN 2001;POPs . 2001

机译：PCB诱导的乳腺癌细胞中COX-2的表达和促炎性细胞因子的激活需要NF-k kk kB的激活
5. The effects of enamel matrix derivative on human gingival fibroblasts in vitro study: Proliferation, differentiation and cytokines expression. [D] . Parthasarathy, Kavitha. 2007

机译：牙釉质基质衍生物对人牙龈成纤维细胞的体外研究：增殖，分化和细胞因子表达。
6. Mechanical stimulation of human dermal fibroblasts regulates pro-inflammatory cytokines: potential insight into soft tissue manual therapies [O] . Aric Anloague, Aaron Mahoney, Oladipupo Ogunbekun, 2020

机译：人体皮肤成纤维细胞的机械刺激调节促炎细胞因子：潜在地洞察软组织手工疗法
7. Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts [O] . Linnéa Asp, Anne-Sofie Johansson, Amandeep Mann, 2011

机译：促炎细胞因子对人皮肤成纤维细胞中犬尿氨酸途径酶表达的影响

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts

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