Chitooligosaccharides compounds for inhibiting the activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts and matrix metalloproteinase-2 inhibitors containing the same

摘要

Chitooligosaccharides compounds are provided to inhibit the activation and expression of matrix metalloproteinase-2(MMP-2) in human dermal fibroblasts, so that they are useful for treatment of disease associated with MMP-2 including wound, metastasis, rheumatoid arthritis, inflammation, hyperparathyroidism, diabetes, corneal ulcer, osteoporosis, gastric ulcer, external wound, acnes, burn scald, periodontal disease, arteriosclerosis and fracture. Chitooligosaccharides(COS) compounds represented by the formula(1) inhibits the activation and expression of matrix metalloproteinase-2 in human dermal fibroblasts, wherein R1 is COCH3 group. The MMP-2 inhibitors contain the chitooligosaccharides compounds represented by the formula(1) and are formulated as powder, tablet, capsule, powder, ointment, solution, gel, paste, patch or granule.