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Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage

机译：褪黑素及其受体拮抗剂对视网膜色素上皮细胞抵抗过氧化氢的影响

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PurposeRecently, we reported finding that circulating melatonin levels in age-related macular degeneration patients were significantly lower than those in age-matched controls. The purpose of this study was to investigate the hypothesis that melatonin deficiency may play a role in the oxidative damage of the retinal pigment epithelium (RPE) by testing the protective effect of melatonin and its receptor antagonist on RPE cells exposed to H2O2 damage.

机译：目的最近，我们报道发现与年龄相关的黄斑变性患者的循环褪黑激素水平显着低于年龄相匹配的对照组。这项研究的目的是通过测试褪黑素及其受体拮抗剂对暴露于H2O2损伤的RPE细胞的保护作用，来研究褪黑激素缺乏可能在视网膜色素上皮（RPE）氧化损伤中起作用的假设。

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期刊名称 Molecular Vision
作者
Richard B. Rosen; Dan-Ning Hu; Min Chen; Steven A. McCormick; Joseph Walsh; Joan E. Roberts;
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作者单位

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年(卷),期 2012(18),-1
年度 2012
页码 1640–1648
总页数 9
原文格式 PDF
正文语种
中图分类分子生物学;眼科学;
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专利

1. Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage [J] . Chen Min, Hu Dan-Ning, McCormick Steven A., Molecular vision . 2012,第2012期

机译：褪黑素及其受体拮抗剂对视网膜色素上皮细胞抵抗过氧化氢的影响
2. Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK [J] . Ning Ma, Xiaolin Yang, Chong Qi, Oxidative Medicine and Cellular Longevity . 2021,第a期

机译：通过激活AKT和MAPK，Farrerol增强了针对过氧化氢致氧化损伤的NRF2介导的防御机制抗过氧化物颜料上皮细胞中的氧化损伤
3. Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway [J] . Xia Zhao, Linlin Liu, Yizhou Jiang, Oxidative Medicine and Cellular Longevity . 2020,第47期

机译：二甲双胍对过氧化氢致氧化损伤在人视网膜色素上皮（RPE）细胞中的氧化损伤通过激活AMPK途径
4. The effects of mechanical and chemical scaffold surface cues on retinal pigment epithelial cells [C] . Corina White, Ronke Olabisi World biomaterials congress . 2016

机译：机械和化学支架表面提示对视网膜色素上皮细胞的影响
5. Extracellular matrix regulation in retinal pigment epithelial cells and role in retinal fibrosis. [D] . Khankan, Rima. 2006

机译：视网膜色素上皮细胞中的细胞外基质调节及其在视网膜纤维化中的作用。
6. Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK [O] . Ning Ma, Xiaolin Yang, Chong Qi, 2021

机译：通过激活AKT和MAPKFarrerol增强了针对过氧化氢致氧化损伤的NRF2介导的防御机制抗过氧化物颜料上皮细胞中的氧化损伤
7. Artemisinin Protects Human Retinal Pigmented Epithelial Cells Against Hydrogen Peroxide-induced Oxidative Damage by Enhancing the Activation of AMP-active Protein Kinase [O] . Shuai Li, Shubhash Chandra chaudhary, Xia Zhao, 2019

机译：青蒿素通过增强AMP活性蛋白激酶的激活来保护人视网膜色素上皮细胞免受过氧化氢致氧化损伤

Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage

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