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Lung and liver SBRT using helical tomotherapy — a dosimetric comparison of fixed jaw and dynamic jaw delivery

机译:螺旋层析疗法对肺和肝脏的SBRT –固定颌骨和动态颌骨递送的剂量学比较

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摘要

The purpose of the study was to evaluate the time effectiveness and dose distribution details of dynamic jaw delivery compared to the regular helical tomotherapy delivery mode in stereotactic body radiation therapy (SBRT) of liver and lung tumors. Ten patients with liver and ten patients with lung tumors were chosen to analyze the dose profiles and treatment times of regular helical tomotherapy delivery (2.5 cm field width) and new helical tomotherapy mode using dynamic jaw delivery with 5 cm field width. A median dose between 24 and 30 Gy was delivered in a single fraction. Regular helical tomotherapy took an average of 31.9 ± 6.7 min (lung SBRT) and 41.7 ± 15.0 min (liver SBRT). A reduction in delivery duration of 38.8% to 19.5 ± 2.9 min could be accomplished for lung irradiation (p < 0.05) and by 50.8% to 20.5 ± 6.0 min for liver SBRT (p < 0.05). Target coverage, as well as conformity and uniformity indices, showed no significant differences. No significant increase in organs‐at‐risk exposure could be detected either for lung or liver tumors. Therefore, use of new delivery mode with dynamic jaws improves treatment efficiency by reducing beam‐on time, while maintaining excellent plan quality.PACS numbers: 87.55.D‐, 87.53.Ly, 87.55.N‐
机译:这项研究的目的是评估与肝脏和肺部肿瘤的立体定向放射疗法(SBRT)中的常规螺旋体层摄影疗法相比,动态颌骨疗法的时间有效性和剂量分布细节。选择十名肝病患者和十名患有肺肿瘤的患者,以分析定期进行螺旋形层析疗法(视野宽度为2.5厘米)和采用动态下颌形扩张术(视野宽度为5厘米)的新型螺旋层析疗法的剂量分布和治疗时间。单次递送的中位剂量为24至30 Gy。常规螺旋断层扫描平均耗时31.9±6.7分钟(肺SBRT)和41.7±15.0分钟(肝脏SBRT)。肺部照射可将分娩持续时间减少38.8%至19.5±2.9分钟(p <0.05),而肝SBRT则可减少50.8%至20.5±6.0分钟(p <0.05)。目标覆盖率以及一致性和均匀性指标均无显着差异。肺或肝肿瘤均未发现有风险的器官显着增加。因此,使用具有动态钳口的新交付模式可通过减少束开时间,同时保持出色的计划质量来提高治疗效率.PACS编号:87.55.D-,87.53.Ly,87.55.N-

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