AIDS defining opportunistic infections in patients with high CD4 counts in the combination antiretroviral therapy (cART) era: things aint what they used to be

摘要

IntroductionAccording to reports from observational databases, classic AIDS-defining opportunistic infections (ADOIs) occur in patients with CD4 counts above 500/µL on and off cART. Adjudication of these events is usually not performed. However, ADOIs are often used as endpoints, for example, in analyses on when to start cART.