In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimers disease with a high specific activity PET imaging agent 18Fflutemetamol

摘要

BackgroundThe purpose of the study was to evaluate the applicability of ^>18F-labelled amyloid imaging positron emission tomography (PET) agent [^>18F]flutemetamol to detect changes in brain beta-amyloid (Aβ) deposition in vivo in APP23, Tg2576 and APPswe-PS1dE9 mouse models of Alzheimer's disease. We expected that the high specific activity of [^>18F]flutemetamol would make it an attractive small animal Aβ imaging agent.