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DAMPD: a manually curated antimicrobial peptide database

机译:DAMPD:手动管理的抗菌肽数据库

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摘要

The demand for antimicrobial peptides (AMPs) is rising because of the increased occurrence of pathogens that are tolerant or resistant to conventional antibiotics. Since naturally occurring AMPs could serve as templates for the development of new anti-infectious agents to which pathogens are not resistant, a resource that contains relevant information on AMP is of great interest. To that extent, we developed the Dragon Antimicrobial Peptide Database (DAMPD, ) that contains 1232 manually curated AMPs. DAMPD is an update and a replacement of the ANTIMIC database. In DAMPD an integrated interface allows in a simple fashion querying based on taxonomy, species, AMP family, citation, keywords and a combination of search terms and fields (Advanced Search). A number of tools such as Blast, ClustalW, HMMER, Hydrocalculator, SignalP, AMP predictor, as well as a number of other resources that provide additional information about the results are also provided and integrated into DAMPD to augment biological analysis of AMPs.
机译:由于对常规抗生素具有耐受性或耐药性的病原体的出现增加,因此对抗菌肽(AMPs)的需求正在增加。由于天然存在的AMP可以用作开发新的抗病原体不抗药的抗感染剂的模板,因此包含AMP相关信息的资源引起了极大的兴趣。在此程度上,我们开发了Dragon抗菌肽数据库(DAMPD,),其中包含1232个手动管理的AMP。 DAMPD是ANTIMIC数据库的更新和替代。在DAMPD中,集成的界面允许以简单的方式基于分类法,物种,AMP家族,引文,关键字以及搜索词和字段的组合进行查询(高级搜索)。还提供了许多工具,例如Blast,ClustalW,HMMER,Hydrocalculator,SignalP,AMP预测器,以及提供有关结果的附加信息的许多其他资源,并将其集成到DAMPD中,以增强AMP的生物学分析。

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