177Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment

摘要

BackgroundMetastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvious morbidity. Common treatments including systemic application of bisphosphonate drugs aim on pain reduction and on improving the quality of life of the patient. Particularly, patients with multiple metastatic lesions benefit from bone-targeting therapeutic radiopharmaceuticals. Agents utilizing beta-emitting radionuclides in routine clinical praxis are, for example, [⁸⁹Sr]SrCl2 and [¹⁵³Sm]Sm-EDTMP. No-carrier-added (n.c.a.) ¹⁷⁷Lu is remarkably suitable for an application in this scope.