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A Phase I trial using local regional treatment nonlethal irradiation intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect

机译：使用局部区域治疗非致死性照射肿瘤内和全身性多肌苷-聚胞苷酸聚赖氨酸羧甲基纤维素治疗肝癌的I期试验：寻找绝对疗效

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PurposeTo determine the safety of an approach to immunologically enhance local treatment of hepatocellular cancer (HCC) by combining nonlethal radiation, local regional therapy with intratumoral injection, and systemic administration of a potent Toll-like receptor (TLR) immune adjuvant.

机译：目的通过结合非致死性放射治疗，局部区域治疗与肿瘤内注射以及全身性施用有效的Toll样受体（TLR）免疫佐剂，确定在免疫学上增强肝细胞癌（HCC）局部治疗方法的安全性。

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期刊名称 Journal of Hepatocellular Carcinoma
作者
Andrew N de la Torre; Sohail Contractor; Ismael Castaneda; Charles S Cathcart; Dolly Razdan; David Klyde; Piotr Kisza; Sharon F Gonzales; Andres M Salazar;
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作者单位

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年(卷),期 2017(4),-1
年度 2017
页码 111–121
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
immunotherapy autologous vaccine liver cancer human trial Toll-like receptor;

机译：免疫疗法;自体疫苗;肝癌;人体试验;Toll样受体;

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1. A Phase I trial using local regional treatment, nonlethal irradiation, intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect [J] . Andrew N de la Torre, Sohail Contractor, Ismael Castaneda, Journal of Hepatocellular Carcinoma . 2017,第1期

机译：使用局部区域治疗，非致死性照射，肿瘤内和全身性多肌苷-聚胞苷酸聚赖氨酸羧甲基纤维素治疗肝癌的I期试验：寻找绝对疗效
2. Outcomes from a Phase II Clinical Trial Evaluating the Systemic (Abscopal) Response from the Addition of Local Radiation to Standard-of-Care Immunotherapy for Metastatic Non-Small Cell Lung Cancer [J] . Mattes M. D., Eubank T. D., Almubarak M., International Journal of Radiation Oncology, Biology, Physics . 2019,第1Suppla期

机译：来自II期临床试验的结果，从添加局部辐射到转移性非小细胞肺癌的局部辐射到治疗标准免疫疗法中评估全身（横断生）反应
3. Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer [J] . Yu Jeong Il, Park Hee Chul, Choi Doo Ho, Radiation Oncology Journal . 2016,第1期

机译：局部热疗和全肝照射治疗结直肠癌的大量化学难治性肝转移的前瞻性II期试验
4. Nutritional Risk in the Cancer Patient 65 and Older Undergoing Systemic Treatment via Phase I Clinical Trials [D] . Williams, Anna Cathy. 2019

机译：癌症患者65岁及以上经受I期临床试验的营养风险
5. Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer [O] . Jeong Il Yu, Hee Chul Park, Doo Ho Choi, 2016

机译：局部热疗和全肝照射治疗结直肠癌的大量化学难治性肝转移的前瞻性II期试验
6. Outcomes from a Phase II Clinical Trial Evaluating the Systemic (Abscopal) Response from the Addition of Local Radiation to Standard-of-Care Immunotherapy for Metastatic Non-Small Cell Lung Cancer [O] . M.D. Mattes, T.D. Eubank, M. Almubarak, 2019

机译：来自II期临床试验的结果，从添加局部辐射到转移性非小细胞肺癌的局部辐射到治疗标准免疫疗法中评估全身（横断生）反应

A Phase I trial using local regional treatment nonlethal irradiation intratumoral and systemic polyinosinic-polycytidylic acid polylysine carboxymethylcellulose to treat liver cancer: in search of the abscopal effect

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