Synthesis of C2‐Symmetric Diphosphormonoamidites and Their Use as Ligands in Rh‐Catalyzed Hydroformylation: Relationships between Activity and Hydrolysis Stability

摘要

A series of diphosphoramidites has been synthetized with a piperazine, homopiperazine, and an acyclic 1,2‐diamine unit in the backbone. New compounds were tested alongside related N‐acyl phosphoramidites as ligands in the Rh‐catalyzed hydroformylation of n‐octenes to investigate their influence on the activity and regioselectivity. A subsequent study of their hydrolysis stability revealed that the most stable ligands induced the highest activity in the catalytic reaction.