Assessment of the effect of direct oral anticoagulants dabigatran rivaroxaban and apixaban in healthy male volunteers using a thrombin generation assay

机译：使用凝血酶生成试验评估直接口服抗凝剂达比加群利伐沙班和阿哌沙班在健康男性志愿者中的作用

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Essentials class="unordered" style="list-style-type:disc" id="rth212044-list-0001">The value of thrombin generation assay (TGA) in monitoring direct oral anticoagulants (DOAC) is not well defined.TGA parameters were measured and correlated to DOAC levels in 10 healthy volunteers after oral intake of DOACs.Lag time is the only sensitive TGA parameter across different DOACs, dabigatran, rivaroxaban and apixaban.Endogenous thrombin potential had weak correlation with DOAC levels and not suitable as stand‐alone parameter.

机译：要点 class =“ unordered” style =“ list-style-type：disc” id =“ rth212044-list-0001”> <！-list-behavior = unordered prefix-word = mark-type = disc max-label -size = 0-> 凝血酶生成测定法（TGA）在监测直接口服抗凝剂（DOAC）中的价值尚未明确。测量TGA参数并将其与10种DOAC水平相关口服DOAC后，健康志愿者。滞后时间是不同DOAC，达比加群，利伐沙班和阿哌沙班之间唯一的敏感TGA参数。内源性凝血酶潜能与DOAC水平和相关性较弱。不适合作为独立参数。

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期刊名称 Research and Practice in Thrombosis and Haemostasis
作者
Ramin Artang; Maren Anderson; Paul Riley; Jorn D. Nielsen;
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作者单位

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年(卷),期 2017(1),2
年度 2017
页码 194–201
总页数 8
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
apixaban dabigatran direct oral anticoagulants rivaroxaban thrombin generation assay;

机译：阿哌沙班;达比加群;直接口服抗凝剂;利伐沙班;凝血酶生成测定;

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专利

1. Assessment of the effect of direct oral anticoagulants dabigatran, rivaroxaban, and apixaban in healthy male volunteers using a thrombin generation assay [J] . Artang Ramin, Anderson Maren, Riley Paul, Research and practice in thrombosis and haemostasis. . 2017,第2期

机译：使用凝血酶生成试验评估直接口服抗凝剂达比加群，利伐沙班和阿哌沙班在健康男性志愿者中的作用
2. Anticoagulant therapy with the oral direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban and the thrombin inhibitor dabigatran etexilate in patients with hepatic impairment. [J] . Jochen Graff, Sebastian Harder Clinical pharmacokinetics . 2013,第4期

机译：在肝功能不全患者中，口服直接Xa抑制剂利伐沙班，阿哌沙班和依多沙班以及凝血酶抑制剂达比加群酯可抗凝治疗。
3. Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants [J] . Journal of thrombosis and haemostasis: JTH . 2014,第10期

机译：超高效液相色谱-串联质谱法（UPLC-MS / MS）和凝血测定法测定达比加群，利伐沙班和阿哌沙班的含量，用于监测新型直接口服抗凝剂的治疗
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
5. Cost-effectiveness of apixaban, dabigatran, rivaroxaban, and warfarin for the prevention of stroke prophylaxis in atrial fibrillation. [D] . Harrington, Amanda. 2012

机译：阿哌沙班，达比加群，利伐沙班和华法林预防房颤预防中风的成本效益。
6. Fully automated thromboelastograph TEG 6s to measure anticoagulant effects of direct oral anticoagulants in healthy male volunteers [O] . Ramin Artang, Maren Anderson, Jorn D. Nielsen 2019

机译：全自动血栓弹力图TEG 6s在健康男性志愿者中测量直接口服抗凝剂的抗凝作用
7. Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants [O] . Schmitz, EMH Ellen, Boonen, K Koen, Heuvel, van den, DJA, 2014

机译：超高效液相色谱-串联质谱法（UPLC-MS / MS）和凝血测定法测定达比加群，利伐沙班和阿哌沙班的含量，用于监测新型直接口服抗凝剂的治疗

Assessment of the effect of direct oral anticoagulants dabigatran rivaroxaban and apixaban in healthy male volunteers using a thrombin generation assay

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