Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin‐specific peptidase 9 X‐linked in oral squamous cell carcinoma

摘要

BackgroundThe immune checkpoint protein programmed cell death ligand 1 (PD‐L1) binds to PD1 to promote tumor cell escape from the killing effect of the immune system. However, there are few studies on the regulatory mechanisms of PD‐L1 in tumors. Although PD‐L1 has been reported to undergo ubiquitination in some cancers, its regulatory mechanisms in oral squamous cell carcinoma (OSCC) are unclear. Therefore, we aimed to investigate this phenomenon.