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Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

机译:提升基于生物无机杂化脂质的组装的药物开发潜力

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摘要

Bioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid‐based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid‐based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed.
机译:模仿天然膜的精细结构的受生物启发的脂质组装件使研究人员着迷了很长时间。这些脂质装配体已经从仅用于生物物理研究的必要平台变成了用于生物医学应用的药物递送系统。尽管取得了成功,但这些有组织的纳米系统经常会遭受机械不稳定性和有限的诊断能力,而不会增加任何不便的修改。为了发挥其先进的药物潜力,最近开发了各种基于生物无机杂化脂质的组合物,它们提供了新的机会来协同补充现有的基于脂质的纳米药物,并通过含有无机嵌入表面活性剂的独特机理提高了治疗/诊断潜力。

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