BACKGROUND—It is not known whether long term nocturnal mechanical ventilation (NMV) reduces pulmonary hypertension in patients with chronic respiratory failure (CRF). METHODS—Pulmonary haemodynamics, spirometric values, and gas exchange were studied in 33 patients requiring NMV due to CRF (20 with thoracic restriction, 13 with chronic obstructive pulmonary disease (COPD)) at baseline and after 1 year of NMV given in the volume cycled mode. Patients with COPD also received supplemental oxygen. RESULTS—Long term NMV improved gas exchange while lung function remained unchanged. Mean pulmonary artery pressure at rest before NMV was higher in patients with thoracic restriction than in those with COPD (33 (10) mm Hg v 25 (6) mm Hg). After 1 year of NMV mean pulmonary artery pressure decreased in patients with thoracic restriction to 25 (6) mm Hg (mean change -8.5 mm Hg (95% CI -12.6 to -4.3), p<0.01) but did not change significantly in patients with COPD (mean change 2.2 mm Hg (95% CI -0.3 to 4.8)). CONCLUSIONS—Long term NMV in CRF improves pulmonary haemodynamics in patients with thoracic restriction but not in patients with COPD.
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机译：背景—长期的夜间机械通气（NMV）是否能降低慢性呼吸衰竭（CRF）患者的肺动脉高压，目前尚不清楚。 方法—在33名需要NMV的患者中研究了肺血流动力学，肺活量和气体交换在容量循环模式下，在基线和NMV 1年后，由于CRF（20例有胸腔受限，13例患有慢性阻塞性肺疾病（COPD））引起。 COPD患者也需要补充氧气。 结果-长期NMV改善了气体交换，而肺功能保持不变。胸椎受限患者的NMV前静息时平均肺动脉压高于COPD患者（33（10）mm Hg vs 25（6）mm Hg）。 NMV 1年后，胸腔受限患者的平均肺动脉压降低至25（6）mm Hg（平均变化-8.5 mm Hg（95％CI -12.6至-4.3），p <0.01），但在2007年无明显变化。 COPD患者（平均变化2.2毫米汞柱（95％CI -0.3至4.8））。 结论— CRF中长期NMV改善了胸腔受限患者的肺血流动力学，但对COPD患者却没有改善。
