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Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages

机译:血清FABP5浓度是与巨噬细胞胆固醇外流有关的动脉粥样硬化残留风险的潜在生物标志物

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摘要

Cholesterol efflux capacity (CEC) from macrophages, the first step in the reverse cholesterol transport pathway, is inversely associated with residual risk for atherosclerotic cardiovascular disease. Fatty acid-binding protein 4 (FABP4) and FABP5 are expressed in both adipocytes and macrophages and play significant roles in the development of insulin resistance and atherosclerosis. Both FABP4 and FABP5 are secreted from cells, and their circulating levels are associated with insulin resistance and atherosclerosis. We investigated the association between CEC and levels of FABP4 and FABP5 in 250 subjects without any medications. CEC was positively correlated with HDL cholesterol level and negatively correlated with concentrations of high-sensitivity C-reactive protein (hsCRP) and FABP5, but not FABP4. Multiple regression analysis demonstrated that FABP5 concentration was an independent predictor of CEC after adjustment of age, gender and levels of HDL cholesterol and hsCRP. In 129 of the 250 subjects who underwent carotid ultrasonography, mean intima-media thickness was negatively correlated with CEC and was positively correlated with concentrations of FABP4 and FABP5. In conclusion, in contrast to FABP4, circulating FABP5 is associated with decreased CEC and carotid atherosclerosis, suggesting that FABP5 level is a regulatory factor of CEC and a potential biomarker for residual risk of atherosclerosis.
机译:巨噬细胞的胆固醇外排能力(CEC)是胆固醇逆向转运途径的第一步,与动脉粥样硬化性心血管疾病的残留风险成反比。脂肪酸结合蛋白4(FABP4)和FABP5在脂肪细胞和巨噬细胞中均表达,并在胰岛素抵抗和动脉粥样硬化的发展中起重要作用。 FABP4和FABP5都是从细胞分泌的,其循环水平与胰岛素抵抗和动脉粥样硬化有关。我们调查了250名未使用任何药物的受试者中CEC与FABP4和FABP5水平之间的关联。 CEC与HDL胆固醇水平呈正相关,与高敏感性C反应蛋白(hsCRP)和FABP5呈负相关,而与FABP4则无负相关。多元回归分析表明,在调整年龄,性别以及HDL胆固醇和hsCRP水平后,FABP5浓度是CEC的独立预测因子。在接受颈动脉超声检查的250位受试者中,有129位的平均内膜中层厚度与CEC呈负相关,与FABP4和FABP5的浓度呈正相关。总之,与FABP4相比,循环FABP5与CEC降低和颈动脉粥样硬化相关,这表明FABP5水平是CEC的调节因子,是动脉粥样硬化残留风险的潜在生物标志物。

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